evidence-based blog of Filippo Dibari

My PhD


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Title: “Design and pre-testing of lipid-based, ready-to-use foods for prevention and treatment of malnutrition in low-resource settings”

successfully submitted and discussed in 2014 at the University College London (Institute for Global Health), University of London.

Supervision: Andrew Seal and Andrew Tomkins.

Financial support: Valid Nutrition

Ethical approval granted by KEMRI (SSC No. 1414) and UCL

Background

Managing child and adult undernutrition is a global public health priority. In poor settings, improved Ready-to-Use Foods (RUFs) are needed for treatment and prevention of undernutrition.

Objective

To develop a method for the design and pre-clinical testing of novel, low-cost, RUF products.

A method was developed and tested. Four sequential studies involved HIV-positive Kenyan adults with severe acute malnutrition.

  1. A qualitative study explored adherence and consumption barriers with the current UN-standard peanut/milk-powder-based formulation (P-RUF).
  1. A study using Linear Programming (LP) designed an improved, cheaper RUF formulation soy/maize/sorghum-based (SMS-RUF).  The formulation was considered accurate if its manufactured prototype, compared to the calculated values, had: a measured energy density difference (EDD) <10%; a protein or lipid difference (P/LD) <5g/100g.
  1. An acceptability study (cross-over design; washout: one-week) compared the use of SMS-RUTF against P-RUF (n=41), using eighteen consumption/safety/preference criteria.
  1. Based on a literature review (28 randomized controlled trials of micronutrient supplementation; outcomes: increased survival and CD4 cell count, reduced viral load), four criteria to determine micronutrient specifications for the SMS-RUF fortification were developed and applied.

Results

  1. The reported compliance with the prescribed RUTF was relatively low, and informed the necessary formulation improvements.
  1. The LP-determined formulation was accurate (EDD: 7%; PD and LD: 2.3 and 1.0g/100g).
  1. The LP-based prototype was acceptable and safe, in spite of the higher average frequency of nausea and vomiting events.
  1. The existing evidence for determining micronutrient specifications for SMS-RUTF posed some challenges for the development of manufacturing specifications. Twelve of the specifications developed for micronutrients for the SMS-RUTF fortificant premix were equivalent to the UN minimum standards; eleven were 2 to 10 times higher.

Conclusions

The proposed set of methods can be used to design and pre-clinically test improved and cheaper RUF products. However, novel formulations should be clinically trialled before widespread use.

Homa Bay hospital (photo by Bannon)

Acceptability and safety trial

Follow-up of this research:

The following papers were written based on my thesis:

The MSF-Scientific day (2008) hosted one presentation . The abstract  is also available on line.

A clinical trial to test the SMS-RUTFh is due to start in the following months.

More publications on related topics are available on a page of this blog.

Interested in the topic of of my PhD? Do not hesitate to contact me for any query.  On the university website, the entire thesis will be available for downloading soon after its discussion with the PhD external examiners.

Interviewing and thanking few of the study participants at the end of the trial.

~ ~ ~

In this page, the pictures were authorized by the study participants.  For more pictures by my  friend Brendan Bannon click here.

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NB – To follow up any further development of my thesis (or any post of this blog), enter your email in the rectangle at the bottom/right side of this page (you can un-subscribe any time)

  1. Congrats,I am facinated and will like you to share ur experience with me.I have a similar work as my Ph.D study in the University of Nigeria, .Thanks

    Like

  2. Please I need to enrolled in IYCF online course,need your support

    Like

    • Hi, where did you apply already? There are a couple of UNICEF modules on this topic. Regards. fil

      Like

  3. Thanks , I have recently been searching for info approximately this subject
    for ages and yours is the greatest I have discovered till now.
    But, what about the bottom line? Are you sure
    in regards to the source?

    Like

  4. I credibly impressed by the research in areas of nutrition and food technology combinations,will contact you during my Msc nutrition research

    Like

    • Dear Fanuel,
      thanks for your comment – good luck with your MSc. Where will you be studying?
      Regards
      fil

      Like

  5. carissimo filippo ti penso sempre, credimi! leggere è facile e partecipare è gradito, buona pasqua!
    http://gamberettarossa.wordpress.com/2013/03/23/liebster-blog-award/

    Like

  6. I am really impressed
    I am a Nutrition Advisor for FBP program in Ethiopia, Please let me know all the findings the processes regarding management of malnutrition in OVC, PLHIV and others

    Like

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