evidence-based blog of Filippo Dibari

Posts Tagged ‘F100’

WHO: Updates on the management of severe acute malnutrition in infants and children Guideline

In Under-nutrition on April 27, 2015 at 7:02 am

(from WHO website)

Publication details

Editors: World Health Organization – 2013
Number of pages: 111
Languages: English, French

(Full document)

Overview

This guideline provides global, evidence-informed recommendations on a number of specific issues related to the management of severe acute malnutrition in infants and children, including in the context of HIV.

The guideline will help Member States and their partners in their efforts to make informed decisions on the appropriate nutrition actions for severely malnourished children. It will also support Member States in their efforts to achieve global targets on the maternal, infant and young child nutrition comprehensive implementation plan, especially global target 1, which entails achieving 40% reduction by 2025 of the global number of children under 5 years who are stunted and global target 6 that aims to reduce and maintain childhood wasting to less than 5%.

The guideline is intended for a wide audience, including policy-makers, their expert advisers, and technical and programme staff in organizations involved in the design, implementation and scaling-up of nutrition actions for public health. The guideline will form the basis for a revised manual on the management of severe malnutrition for physicians and other senior health workers, and a training course on the management of severe malnutrition.

Evidence

Locally-Prepared Ready-to-Use Therapeutic Food for Children with Severe Acute Malnutrition: A Controlled Trial

In Under-nutrition on June 4, 2013 at 8:14 pm

by Govind Singh Thakur, HP Singhand Chhavi Patel

Indian Pediatrics – Vol. 50, March 16 2013

(download the paper)

Abstract

Objective: To compare the efficacy of locally-prepared ready-to-use therapeutic food (LRUTF) and locally-prepared F100 diet in promoting weight-gain in children with severe acute malnutrition during rehabilitation phase in hospital.

Study design: Non-randomized Controlled trial.
Setting: Pediatric ward of tertiary care public hospital in Central India.
Study period: 1 October, 2009 to 30th May, 2010.
Subjects: Children aged 6 to 60 months, diagnosed as severe acute malnutrition and hospitalized during study period.

Intervention: Random group allocation followed for selection of intervention and control cohorts. The control cohort enrolled during October 1, 2009 to January 31, 2010 received F100 while the intervention cohort enrolled during 1 February to 15 May 2010 received LRUTF. Subjects receiving either of the two therapeutic foods were temporally separated to minimize the spillover effect. The study subjects and the technician delegated for measuring weight was blinded for type of intervention.

Primary outcome variable: Rate of weight-gain/kg/day.

Results: There were 49 subjects in each group. Both groups were comparable. Rate of weight-gain was found to be (9.59±3.39 g/kg/d) in LRUTF group and (5.41 ± 1.05 g/kg/d) in locally prepared F100 group. Significant difference in rate of weight gain was observed in LRUTF group (P<0.0001; 95% CI 3.17-5.19). No serious adverse effect was observed with use of LRUTF.
Conclusion: LRUTF promotes more rapid weight-gain when compared with F100 in patients with severe acute malnutrition during rehabilitation phase.

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